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Creatine Loading Delays Neuromuscular Fatigue in Cycling In a study recently published in the Journal of the International Society of Sports Nutrition, researchers sought to determine the effect of five days of creatine loading on the electromyographic fatigue threshold of women during stationary cycling. The electromyographic fatigue threshold is the point at which electrical activity in the working muscles decreases--indicating reduced motor output from the brain--during a high-intensity exercise bout.  Fifteen healthy, college-age women participated in the study. Seven subjects ingested 20 grams of creatine daily after completing an initial incremental exercise test on a stationary bike and before repeating the same test. The other eight subjects consumed a placebo. Subjects completed a total of four, 60-second work bouts ranging from 100-350 watts. The EMG amplitude was averaged over 10-second intervals and plotted over the 60 second work bout. The resulting slopes from each successive work bouts were used to calculate electromyographic fatigue threshold. On average, the electromyographic fatigue threshold was found to increase by 14.5% in the creatine loading group. This means they were able to sustain a 14.5% greater power output before showing evidence of fatigue. There was no increase in the control group. The study authors concluded, "These findings suggest that 5 days of creatine loading in women may be an effective strategy for delaying the onset of neuromuscular fatigue during cycle ergometry."

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