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CoQ10 Supplementation Delays Exercise Fatigue in Study A new study conducted by researchers from Osaka City University Graduate School of Medicine, Soiken Incorporation, Kansai University of Welfare Sciences, and Osaka University of Foreign Study and published in the journal Nutrition investigated the effects of eight days of CoQ10 supplementation at two levels--100 mg per day and 300 mg per day--on exercise performance and perception of fatigue in 17 volunteers. All subjects rode stationary bikes to exhaustion at a fixed intensity on three occasions separated by washout periods. One trial was preceded by eight days of CoQ10 supplementation at 100 mg/day. A second trial was preceded by eight days of CoQ10 supplementation at a level of 300 mg/day. And a third trial was preceded by an eight-day placebo treatment. Time to exhaustion was found to be significantly greater in the 300 mg trial than in both the 100 mg and placebo trials. There was no significant difference in performance between the 100 mg and placebo trials. Perceptions of fatigue were also reduced by 300 mg of CoQ10 supplementation. The authors of the study speculated that, at adequate doses, CoQ10 might delay exercise fatigue through its role in aerobic energy metabolism and its function as an antioxidant. Previous research on the ergogenic effects of CoQ10 supplementation has produced mixed results .

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