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Resveratrol Makes Old Mice Run Young Resveratrol is a compound in red wine that belongs to a class of nutrients called polyphenols, many of which function as antioxidants.  Past research has shown that resveratrol increases lifespan and exercise capacity in mice by enhancing mitochondrial function. Now a new study out of Japan has shown that it decelerates the aging-related decline in exercise performance in mice.  Two groups of senscence-accelerated muscle were studied for 12 weeks. Both groups exercised regularly but one group also received resveratrol supplementation. Exercise performance declined steady in the exercise-only group, but held steady in the exercise-plus-reseveratrol group. The researchers found increased expression of enzymes related to mitochondrial function in the resveratrol-supplemented mice.  They concluded, "These results suggest that the intake of resveratrol, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and that these effects are attributable, at least in part, to improved mitochondrial function in skeletal muscle." The study was published in Biogerontology.

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